In fact our experiment results were consonant with previous studies. Many researches have proved that Hippo pathway in mammalian is involved in cell proliferation, apoptosis, migration and differentiation [31]. As the switch protein, YAP plays a central role in the Hippo signaling pathway. In the process of normal growth and development, YAP can bind transcription factor TEAD to promote the expression of downstream target genes, so as to accelerate cells growth and inhibit cells apoptosis. Undifferentiated progenitor cells get obvious expansion because of the over expression of YAP [13], both multifunctional knockout and RNA interference of YAP reduce the multi-differentiated potentiality of stem cells significantly, and the expression of genes Oct4 and Sox2 that maintain stem cells characteristics decrease greatly as well [32].Recent investigations demonstrate that YAP gene is involved in the self-renewal of stem cells [33, 34].The study of neural progenitor cells indicates that over expression of YAP could not only inhibit its differentiation, but also enhance its mass proliferation; YAP is also expressed in intestinal epithelial precursor cells located in the small intestine of normal mice, which means YAP takes part in regulating tissue-specific precursor cells, furthermore, YAP over expression can regulate precursor cells proliferation significantly, while inhibits precursor cells from differentiating into mature terminal cells [13].Thus, YAP has a significant effect on maintaining self-renewal and differentiation of stem cells as a gene transcriptional co-activator. And the action of promoting proliferation of YAP is closely related to TEAD, moreover, the activation of YAP/TEAD facilitates expression of related genes such as cyclin D1, while it inhibits stem cells exiting the cell cycle and cells apoptosis, which is conducive to the proliferation of stem cells. As an important kind of stem cells, h-PDLSCs were proved to participate in maintaining the balance of periodontal ligament through orient migration and differentiation [35]. Since the regulation mechanism of proliferation, apoptosis and senescence in h-PDLSCs remains uncertain until now, we suggested that Hippo pathway took part in this regulation process. Our results proved that knocking down YAP induced the apoptosis and inhibited the proliferation of h-PDLSCs.. which the senescence was induced by γ-irradiation [33] or by

which the senescence was induced by γ-irradiation [33] or by.

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